Abstract |
There is a group of less-common movement disorders in which a clear cognitive phenotype coexists alongside the motor abnormality, and the recognition of this co-occurrence is essential to diagnose these disorders in an early phase. Examples include chorea-acanthocytosis, Niemann-Pick type C, some dominant ataxias, and pantothotenate kinase-associated neurodegeneration. However, also, in some more-common movement disorders, such as primary dystonia and essential tremor, of which the perception is that these have a more or less pure motor phenotype, cognitive deficits are commonly present, although it is not clear whether these deficits-which may be mild in the more "pure" motor disorders-have a functionally relevant impact. In both scenarios, disruption of relevant frontal-subcortical loops appears to be key, with the striatum and cerebellum as important (but not exclusive) nodes.
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Authors | Mark Walterfang, Bart P van de Warrenburg |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 29
Issue 5
Pg. 694-703
(Apr 15 2014)
ISSN: 1531-8257 [Electronic] United States |
PMID | 24757117
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2014 International Parkinson and Movement Disorder Society. |
Topics |
- Animals
- Brain
(pathology)
- Cognition
(physiology)
- Cognition Disorders
(complications, diagnosis, physiopathology)
- Essential Tremor
(physiopathology)
- Humans
- Movement Disorders
(diagnosis, etiology, physiopathology)
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