HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.

Abstract
Melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. Three key enzymes, tyrosinase, tyrosinase-related protein 1 (TRP1) and TRP2, metabolize melanin from L-tyrosine. Melanin synthesizing enzymes are regulated by microphthalmia-associated transcription factor (MITF). The titrated extract of Centella asiatica (TECA) contains the major components asiatic acid, asiaticoside and madecassic acid. The present study revealed that TECA reduces the melanin content in melanocytes. Moreover, the asiaticoside contained in TECA modulated melanogenesis by inhibiting tyrosinase mRNA expression. The decrease in tyrosinase mRNA levels was mediated through MITF. Uniquely, asiaticoside inhibited MITF by decreasing its DNA binding affinity. In conclusion, the results of the present study indicate that asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening.
AuthorsKu Jung Kwon, Seunghee Bae, Karam Kim, In Sook An, Kyu Joong Ahn, Sungkwan An, Hwa Jun Cha
JournalMolecular medicine reports (Mol Med Rep) Vol. 10 Issue 1 Pg. 503-7 (Jul 2014) ISSN: 1791-3004 [Electronic] Greece
PMID24756377 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents
  • Melanins
  • Microphthalmia-Associated Transcription Factor
  • Triterpenes
  • DNA
  • Monophenol Monooxygenase
  • asiaticoside
Topics
  • Animals
  • Anti-Infective Agents (pharmacology)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Centella (chemistry, metabolism)
  • DNA (metabolism)
  • Down-Regulation (drug effects)
  • Melanins (biosynthesis)
  • Melanocytes (drug effects, metabolism)
  • Melanoma, Experimental (metabolism, pathology)
  • Mice
  • Microphthalmia-Associated Transcription Factor (metabolism)
  • Monophenol Monooxygenase (genetics, metabolism)
  • Protein Binding
  • Triterpenes (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: