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Immunohistochemical and fluorescent microscopic study of histogenesis of salivary mucoepidermoid carcinoma.

Abstract
The purpose of the present investigation was to study the histogenesis of the mucoepidermoid carcinoma of the salivary glands. Eleven cases of mucoepidermoid carcinoma of the minor salivary glands and five of the major glands were extensively studied employing immunohistochemical and fluorescent microscopic techniques. Both the intermediate cells and the duct cells showed a rather similar pattern of reactivity for vimentin, actin and EMA. Also, the intermediate cells and the myoepithelial cells showed a similar reaction pattern for keratin and UGA-1. The intermediate, myoepithelial and duct cells shared a similar reaction pattern for desmin, myosin, CEA, and S-100 protein. However, the rest of the tumor markers studied (AFP, PNA and WGA) were found to be non contributary. We also found that the intermediate and to some extent the epidermoid tumor cells showed a positive reaction with Azophloxine GA, which is a selective stain for myoepithelial cells in the normal glands. Based on these findings, the duct cells, the myoepithelial cell in the normal glands and the intermediate cells of the mucoepidermoid carcinoma share certain similar characteristics. The intermediate cells may actually be a mixed population, some having characteristics of the myopithelial cells and others of duct cells. These findings are relevant to the possible role of the intermediate cell in the histogenesis of the mucoepidermoid carcinoma.
AuthorsM B Hassanin, L Ghosh, A K Das, J P Waterhouse
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 18 Issue 5 Pg. 291-8 (May 1989) ISSN: 0904-2512 [Print] Denmark
PMID2475619 (Publication Type: Journal Article)
Chemical References
  • Actins
  • Antigens, Neoplasm
  • Antigens, Surface
  • Azo Compounds
  • Biomarkers, Tumor
  • Carcinoembryonic Antigen
  • Coloring Agents
  • Naphthalenesulfonates
  • S100 Proteins
  • Vimentin
  • red 2G
  • Keratins
Topics
  • Actins (analysis)
  • Antigens, Neoplasm (analysis)
  • Antigens, Surface (analysis)
  • Azo Compounds
  • Biomarkers, Tumor (analysis)
  • Carcinoembryonic Antigen (analysis)
  • Carcinoma (analysis, pathology)
  • Coloring Agents
  • Humans
  • Immunoenzyme Techniques
  • Immunohistochemistry
  • Keratins (analysis)
  • Microscopy, Fluorescence
  • Naphthalenesulfonates
  • S100 Proteins (analysis)
  • Salivary Gland Neoplasms (analysis, pathology)
  • Salivary Glands, Minor (pathology)
  • Staining and Labeling
  • Vimentin (analysis)

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