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Rat nucleolar 7-2 RNA is homologous to mouse mitochondrial RNase mitochondrial RNA-processing RNA.

Abstract
7-2 RNA (also termed RNA M and 7SM RNA) is a noncapped small RNA present in small ribonucleoprotein particles; these particles are present in the granular compartment of the nucleolus. Some sera from patients with scleroderma specifically immunoprecipitate 7-2 RNA-containing particles (Hashimoto, C., and Steitz, J. A. (1983) J. Biol. Chem. 258, 1379-1382; Reddy, R., Tan, E. M., Henning, D., Nohga, K., and Busch, H. (1983) J. Biol. Chem. 258, 1383-1386; Reimer, G., Raska, I., Scheer, U., and Tan, E.M. (1988) Exp. Cell Res. 176, 117-128). In this study, the primary sequence of Novikoff hepatoma 7-2 RNA was determined and a possible secondary structure is presented. The Novikoff hepatoma 7-2 RNA is 94% homologous to the recently described mouse mitochondrial RNase MRP RNA, suggesting that Novikoff hepatoma 7-2 RNA may be the homologue of mouse MRP RNA. The presence of 7-2 RNA in nucleoli and in mitochondria suggests that 7-2 ribonucleoproteins, in addition to being essential components of mitochondrial RNase, may also be functional in nucleolar RNA processing and ribosome biogenesis.
AuthorsY Yuan, R Singh, R Reddy
JournalThe Journal of biological chemistry (J Biol Chem) Vol. 264 Issue 25 Pg. 14835-9 (Sep 05 1989) ISSN: 0021-9258 [Print] United States
PMID2475491 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Oligonucleotides
  • RNA, Mitochondrial
  • RNA, Ribosomal
  • RNA, Small Nuclear
  • RNA
  • Exoribonucleases
  • Ribonucleases
  • exoribonuclease T
Topics
  • Animals
  • Base Sequence
  • Carcinoma, Hepatocellular (genetics)
  • Cell Line
  • Cell Nucleolus (analysis, enzymology)
  • Exoribonucleases (isolation & purification)
  • Liver Neoplasms (genetics)
  • Mice
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Oligonucleotides (isolation & purification)
  • RNA (genetics, isolation & purification)
  • RNA Processing, Post-Transcriptional
  • RNA, Mitochondrial
  • RNA, Ribosomal (metabolism)
  • RNA, Small Nuclear (genetics, isolation & purification)
  • Rats
  • Ribonucleases (genetics)
  • Sequence Homology, Nucleic Acid

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