[Effect of carbon tetrachloride and chloroform on hematologic parameters in rats].

Abstract

While the hepato- and nephrotoxicity of carbon tetrachloride (CCl4) in men and animals are well characterized, little is known about the haematological effects of CCl4 poisoning. Therefore some haematological parameters were investigated after oral administration of CCl4 and the CCl4-metabolite chloroform in rats. The haemoglobin concentration in the blood was significantly reduced 7 days after administration of CCl4. Chloroform produced a decrease of the relative reticulocyte count at the same time. All effects are moderate and reversible.

• Authors: R P Moritz, D Pankow
• Journal: Folia haematologica (Leipzig, Germany : 1928) (Folia Haematol Int Mag Klin Morphol Blutforsch) Vol. 116 Issue 2 Pg. 283-7 ( 1989) ISSN: 0323-4347 [Print] Germany
• Vernacular Title: Einfluss von Tetrachlorkohlenstoff und Chloroform auf hämatologische Parameter bei Ratten.
• PMID: 2475409 (Publication Type: Journal Article)

Chemical References

• Chloroform
• Carbon Tetrachloride

Topics

• Animals
• Carbon Tetrachloride (toxicity)
• Chemical and Drug Induced Liver Injury (blood)
• Chloroform (toxicity)
• Erythrocyte Count (drug effects)
• Hematocrit
• Hemoglobinometry
• Male
• Rats
• Reticulocytes (drug effects)