Abstract | PURPOSE: Severe oxidative stress is an important event that occurs in patients with sepsis. The body has extensive and multiple defense mechanisms against the reactive oxygen species (ROS) produced during inflammation and sepsis. One of these mechanisms includes a group of enzymes that utilize selenium as their cofactor. The purpose of this study is investigating of Selenium effect on oxidative stress factors in animal model of sepsis. METHODS:
Sepsis was induced by caecal ligation and puncture (CLP) method. 30 Male Wistar rats were divided into following groups: sham group; CLP group; 100 μg/kg Selenium- treated CLP group. 12 hours after inducing sepsis animals were killed and lungs were removed. One of the lungs was frozen in liquid nitrogen and kept at -70°C for enzymatic activity analysis and the other was kept in formalin 10% until tissue section preparation performed for histopathological studies. RESULTS: CONCLUSION:
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Authors | Elmira Zolali, Hadi Hamishehkar, Nasrin Maleki-Dizaji, Naime Majidi Zolbanin, Hamed Ghavimi, Maryam Kouhsoltani, Parina Asgharian |
Journal | Advanced pharmaceutical bulletin
(Adv Pharm Bull)
Vol. 4
Issue 3
Pg. 289-93
( 2014)
ISSN: 2228-5881 [Print] Iran |
PMID | 24754014
(Publication Type: Journal Article)
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