Increased calcium absorption from synthetic stable amorphous calcium carbonate: double-blind randomized crossover clinical trial in postmenopausal women.

Abstract

Calcium supplementation is a widely recognized strategy for achieving adequate calcium intake. We designed this blinded, randomized, crossover interventional trial to compare the bioavailability of a new stable synthetic amorphous calcium carbonate (ACC) with that of crystalline calcium carbonate (CCC) using the dual stable isotope technique. The study was conducted in the Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Israel. The study population included 15 early postmenopausal women aged 54.9 ± 2.8 (mean ± SD) years with no history of major medical illness or metabolic bone disorder, excess calcium intake, or vitamin D deficiency. Standardized breakfast was followed by randomly provided CCC or ACC capsules containing 192 mg elemental calcium labeled with 44Ca at intervals of at least 3 weeks. After swallowing the capsules, intravenous CaCl2 labeled with 42Ca on was administered on each occasion. Fractional calcium absorption (FCA) of ACC and CCC was calculated from the 24-hour urine collection following calcium administration. The results indicated that FCA of ACC was doubled (± 0.96 SD) on average compared to that of CCC (p < 0.02). The higher absorption of the synthetic stable ACC may serve as a more efficacious way of calcium supplementation.

• Authors: Nachum Vaisman, Galit Shaltiel, Michal Daniely, Oren E Meiron, Assaf Shechter, Steven A Abrams, Eva Niv, Yami Shapira, Amir Sagi
• Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (J Bone Miner Res) Vol. 29 Issue 10 Pg. 2203-9 (Oct 2014) ISSN: 1523-4681 [Electronic] United States
• PMID: 24753014 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 American Society for Bone and Mineral Research.

Chemical References

• Calcium Carbonate
• Calcium

Topics

• Calcium (metabolism)
• Calcium Carbonate (administration & dosage, pharmacology)
• Cross-Over Studies
• Crystallization
• Double-Blind Method
• Female
• Humans
• Intestinal Absorption (drug effects)
• Middle Aged
• Postmenopause (drug effects, physiology)