Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Danhong injection (DHI), a Chinese medical product extracted from Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese), has been reported to have anti-inflammatory, anti-oxidative and anti-fibrinolytic properties and is used extensively for the clinical treatment of cardiovascular disease in clinic. This study aimed to investigate the preventive and therapeutic effects of DHI on hyperlipidemia. MATERIALS AND METHODS: RESULTS: Compared with the MC group, rats treated with DHI had significantly reduced TG, TC, LDL-C and arteriosclerosis index (AI). Expression of FAS and HMGR mRNA was significantly reduced, whereas the CPT1 and PPAR-α were significantly increased. CONCLUSION: DHI treatment was accompanied by significantly increased lipolysis in the liver and decreased fatty acid synthesis. The insights gained from this study will improve both understanding of the mechanisms involved in the effect of DHI on hyperlipidemia and the pharmacological rationale for the use of DHI in diseases caused by lipid metabolic disorders.
|
Authors | Juan Chen, Jun Deng, Yuyan Zhang, Jiehong Yang, Yu He, Wei Fu, Panke Xing, Hai tong Wan |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 154
Issue 2
Pg. 437-42
(Jun 11 2014)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 24751362
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Drugs, Chinese Herbal
- Hypolipidemic Agents
- Insulin
- Lipids
- danhong
|
Topics |
- Animals
- Blood Glucose
(analysis)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(administration & dosage, isolation & purification, therapeutic use)
- Ethnopharmacology
- Gene Expression
(drug effects)
- Hyperlipidemias
(blood, drug therapy, enzymology)
- Hypolipidemic Agents
(administration & dosage, isolation & purification, therapeutic use)
- Insulin
(blood)
- Lipids
(blood)
- Liver
(drug effects, enzymology, metabolism)
- Male
- Rats, Sprague-Dawley
- Real-Time Polymerase Chain Reaction
|