Comparative uptake of ¹⁸F-FEN-DPAZn2, ¹⁸F-FECH, ¹⁸F-fluoride, and ¹⁸F-FDG in fibrosarcoma and aseptic inflammation.

Abstract

The aim of this study is to evaluate uptake of 2-(18)F-fluoroethyl-bis(zinc(II)-dipicolylamine) ((18)F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog (18)F-fluoroethylcholine ((18)F-FECH), (18)F-fluoride as a bone imaging agent, and a glucose analog 2-(18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models. The results showed that (18)F-FDG had the highest tumor-to-blood uptake ratio and tumor-to-muscle ratio, and high inflammation-to-blood ratio and inflammation-to-muscle ratio. (18)F -FECH showed moderate tumor-to-blood ratio and tumor-to-muscle ratio, and low inflammation-to-blood ratio and inflammation-to-muscle ratio. However, accumulation of (18)F FEN-DPAZn2 in tumor was similar to that in normal muscle. Also, (18)F-FEN-DPAZn2 and (18)F-fluoride exhibited the best selectivity to inflammation. (18)F-FECH positron emission tomography (PET) imaging demonstrates some advantages over (18)F-FDG PET for the differentiation of tumor from inflammation. (18)F FEN-DPAZn2 and (18)F-fluoride can be used for PET imaging of aseptic inflammation.

• Authors: Xiang Liang, Ganghua Tang, Hongliang Wang, Kongzhen Hu, Xiaolan Tang, Dahong Nie, Ting Sun, Tingting Huang
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 90 Pg. 158-64 (Aug 2014) ISSN: 1872-9800 [Electronic] England
• PMID: 24751349 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Fluorine Radioisotopes
• Organometallic Compounds
• Picolinic Acids
• bis-dipicolylamine-Zinc(II)
• Fluorodeoxyglucose F18
• fluoroethylcholine
• Choline
• Fluorides
• Turpentine

Topics

• Animals
• Bacterial Infections (chemically induced, diagnostic imaging, metabolism)
• Cell Line, Tumor
• Choline (analogs & derivatives, pharmacokinetics)
• Diagnosis, Differential
• Female
• Fibrosarcoma (diagnostic imaging, metabolism)
• Fluorides (pharmacokinetics)
• Fluorine Radioisotopes (pharmacokinetics)
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Inflammation (chemically induced, diagnostic imaging, metabolism)
• Male
• Metabolic Clearance Rate
• Mice
• Organ Specificity
• Organometallic Compounds (pharmacokinetics)
• Picolinic Acids (pharmacokinetics)
• Radionuclide Imaging
• Reproducibility of Results
• Sensitivity and Specificity
• Tissue Distribution
• Turpentine