Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin.

Abstract

Septic arthritis is a rare complication of typhoid fever. A 12-year-old boy without pre-existing disease attended a paediatric hospital in Cambodia with fever and left hip pain. A hip synovial fluid aspirate grew multidrug-resistant Salmonella enterica ser. Typhi with intermediate susceptibility to ciprofloxacin. Arthrotomy, 2 weeks of intravenous ceftriaxone and 4 weeks of oral azithromycin led to resolution of symptoms. The optimum management of septic arthritis in drug-resistant typhoid is undefined.

• Authors: J M Pocock, P A Khun, C E Moore, S Vuthy, N Stoesser, C M Parry
• Journal: Paediatrics and international child health (Paediatr Int Child Health) Vol. 34 Issue 3 Pg. 227-9 (Aug 2014) ISSN: 2046-9055 [Electronic] England
• PMID: 24749773 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Ceftriaxone
• Azithromycin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Arthritis, Infectious (diagnosis, drug therapy, microbiology, pathology)
• Azithromycin (therapeutic use)
• Cambodia
• Ceftriaxone (therapeutic use)
• Child
• Debridement
• Drug Resistance, Multiple, Bacterial
• Hip Joint (pathology)
• Humans
• Male
• Microbial Sensitivity Tests
• Salmonella typhi (drug effects, isolation & purification)
• Synovial Fluid (microbiology)
• Treatment Outcome
• Typhoid Fever (diagnosis, drug therapy, microbiology, pathology)