Periapical tissue reaction to calcium phosphate root canal sealer in porcine model.
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| Abstract | BACKGROUND:
Calcium phosphate cements (CPC) are a group of biomaterials possessing wide scope of use in various branches of medical science. These materials have been proposed to be highly biocompatible and osteoconductive. This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model. OBJECTIVE: To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply). MATERIALS AND METHODS: The procedure was done on porcine animal model following the ISO 7405 criteria. The material was implanted intentionally into the periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods. Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods. RESULTS: Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation. Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation. CONCLUSIONS:
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| Authors | George M Jacob, Ajay Kumar, Jolly Mary Varughese, N O Varghese, P R Harikrishna Varma, Manoj Komath |
| Journal | Indian journal of dental research : official publication of Indian Society for Dental Research (Indian J Dent Res) 2014 Jan-Feb Vol. 25 Issue 1 Pg. 22-7 ISSN: 1998-3603 [Electronic] India |
| PMID | 24748293 (Publication Type: Journal Article) |
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