Synthesis, spectroscopic, anticancer and antibacterial studies of Ni(II) and Cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone.

Abstract

Ni(II) and Cu(II) complexes of 2-carboxybenzaldehyde thiosemicarbazone (L) were synthesized and investigated by their spectral and analytical data. These newly synthesized complexes have a composition of M(L)X(H2O)2 (where M=Ni(II), Cu(II) and X=Cl(-), NO3(-), CH3COO(-)) and (L) is the tridentate Schiff base ligand. The ligand and its complexes have been characterized on the basis of analytical, molar conductivity, magnetic susceptibility measurements, FT-IR, ESR, (1)H NMR and electronic spectral analysis. All the compounds were non-electrolytic in nature. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) and a tetragonal geometry for Cu(II) complexes. The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby-Bauer single disk susceptibility test.

• Authors: Sulekh Chandra, Vandana
• Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (Spectrochim Acta A Mol Biomol Spectrosc) Vol. 129 Pg. 333-8 (Aug 14 2014) ISSN: 1873-3557 [Electronic] England
• PMID: 24747857 (Publication Type: Journal Article)
• Copyright: Copyright © 2014. Published by Elsevier B.V.

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• Coordination Complexes
• Schiff Bases
• Thiosemicarbazones
• Copper
• Nickel

Topics

• Anti-Bacterial Agents (chemical synthesis, chemistry, pharmacology)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Bacteria (drug effects)
• Bacterial Infections (drug therapy)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Coordination Complexes (chemical synthesis, chemistry, pharmacology)
• Copper (chemistry, pharmacology)
• Female
• Humans
• Nickel (chemistry, pharmacology)
• Schiff Bases (chemical synthesis, chemistry, pharmacology)
• Spectrum Analysis
• Thiosemicarbazones (chemical synthesis, chemistry, pharmacology)