Abstract | BACKGROUND: MATERIALS AND METHODS: A retrospective case-control study was performed at our institution involving consecutive ADPKD and non- ADPKD chronic kidney disease (CKD) patients seen over a 13 year period with both chest CT and PFT. CTs were independently reviewed by two blinded thoracic radiologists. Manually collected clinical data included symptoms, smoker status, transplant history, and PFT findings. RESULTS: Ninety-two ADPKD and 95 non- ADPKD CKD control patients were compared. Increased prevalence of radiologic bronchiectasis, predominantly mild lower lobe disease, was found in ADPKD patients compared to CKD control (19 vs. 9%, Pā=ā0.032, OR 2.49 (CI 1.1-5.8)). After adjustment for covariates, ADPKD was associated with increased risk of radiologic bronchiectasis (OR 2.78 (CI 1.16-7.12)). Symptomatic bronchiectasis occurred in approximately a third of ADPKD patients with radiologic disease. Smoking was associated with increased radiologic bronchiectasis in ADPKD patients (OR 3.59, CI 1.23-12.1). CONCLUSIONS: Radiological bronchiectasis is increased in patients with ADPKD particularly those with smoking history as compared to non- ADPKD CKD controls. A third of such patients have symptomatic disease. Bronchiectasis should be considered in the differential in ADPKD patients with respiratory symptoms and smoking history.
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Authors | Teng Moua, Ladan Zand, Robert P Hartman, Thomas E Hartman, Dingxin Qin, Tobias Peikert, Qi Qian |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 4
Pg. e93674
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24747723
(Publication Type: Journal Article)
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Topics |
- Bronchiectasis
(complications, diagnostic imaging, physiopathology)
- Female
- Humans
- Male
- Middle Aged
- Polycystic Kidney, Autosomal Dominant
(complications)
- Regression Analysis
- Respiratory Function Tests
- Retrospective Studies
- Tomography, X-Ray Computed
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