Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson's disease.

Abstract

Ethanol extract (GP-EX) of Gynostemma pentaphyllum (GP) ameliorates chronic stress-induced anxiety in mice. The present study investigated the effects of gypenoside-enriched components (GPS), GP-EX and water extract of GP (GP-WX) on MPTP lesion-induced affective disorders in C57BL/6 mice. GPS (50mg/kg) and GP-EX (50mg/kg) for 21 day-treatment period improved the symptom of anxiety disorders in the MPTP-lesioned mouse model of PD with or without L-DOPA treatment, which was examined by the elevated plus-maze and marble burying tests. In these states, treatments with GPS (50mg/kg) and GP-EX (50mg/kg) significantly increased the brain levels of dopamine and serotonin in the MPTP-lesioned mouse model of PD with or without l-DOPA treatment. In addition, treatments with GPS (50mg/kg) and GP-EX (50mg/kg) showed protective effects on dopaminergic neurons in MPTP-lesioned mouse model of PD with or without L-DOPA treatment. In contrast, GPS (30 mg/kg) and GP-WX (50mg/kg) showed anxiolytic effects in the same animal models, but it was not significant. These results suggest that GPS (50mg/kg) and GP-EX (50mg/kg) showed anxiolytic effects on affective disorders and protective effects on dopaminergic neurons by modulating the brain levels of dopamine and serotonin in the MPTP-lesioned mouse model of PD with or without l-DOPA treatment. Clinical trials of GPS and GP-EX need to be conducted further so as to develop adjuvant therapeutic agents for PD patients.

• Authors: Keon Sung Shin, Ting Ting Zhao, Hyun Sook Choi, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Lee
• Journal: Brain research (Brain Res) Vol. 1567 Pg. 57-65 (Jun 03 2014) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 24747613 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Anxiety Agents
• Antiparkinson Agents
• Neuroprotective Agents
• Plant Extracts
• gypenoside
• Water
• Serotonin
• Ethanol
• Levodopa
• Dopamine

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Antiparkinson Agents (pharmacology)
• Anxiety Disorders (drug therapy, etiology, pathology, physiopathology)
• Behavior, Animal (drug effects)
• Brain (drug effects, pathology, physiopathology)
• Dopamine (metabolism)
• Dopaminergic Neurons (drug effects, pathology, physiology)
• Ethanol (chemistry)
• Gynostemma
• Levodopa (pharmacology)
• Male
• Maze Learning (drug effects)
• Mice, Inbred C57BL
• Neuroprotective Agents (pharmacology)
• Neuropsychological Tests
• Parkinsonian Disorders (complications, drug therapy, pathology, physiopathology)
• Phytotherapy
• Plant Extracts (isolation & purification, pharmacology)
• Serotonin (metabolism)
• Water (chemistry)