Antibody humanization methods for development of therapeutic applications.

Abstract

Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promising alternative therapeutic agent. There are several approaches for antibody humanization. In this article we review various methods used in the antibody humanization process.

• Authors: Vahideh Ahmadzadeh, Safar Farajnia, Mohammad Ali Hosseinpour Feizi, Ramezan Ali Khavari Nejad
• Journal: Monoclonal antibodies in immunodiagnosis and immunotherapy (Monoclon Antib Immunodiagn Immunother) Vol. 33 Issue 2 Pg. 67-73 (Apr 2014) ISSN: 2167-9436 [Electronic] United States
• PMID: 24746146 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Complementarity Determining Regions

Topics

• Amino Acid Substitution
• Animals
• Antibodies, Monoclonal, Humanized (biosynthesis, genetics, therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Complementarity Determining Regions (biosynthesis, genetics)
• Humans
• Protein Engineering (methods)