Synthesis and anti-BVDV activity of novel δ-sultones in vitro: implications for HCV therapies.

Abstract

In this study we report the synthesis and activity against bovine viral diarrhea virus (BVDV) of a novel series of bicycle δ-sultones containing γ-lactones. BVDV is responsible for major losses in cattle. Some of the synthesized δ-sultones showed pronounced anti-BVDV activity with EC50 values of 0.12-1.0μM and no significant cytotoxicity. Among them, the ortho bromosubstituted derivative 4f (EC50=0.12μM) showed better antiviral activity than other derivatives and was 10 fold more that of than positive control ribavirin (EC50=1.3μM). BVDV is also considered to be a valuable surrogate for the hepatitis C virus (HCV) in antiviral drug studies. The above results provided a novel candidate for the development of anti-HCV agents.

• Authors: Hai-Wei Xu, Ling-Jie Zhao, Huan-Fei Liu, Dan Zhao, Jiao Luo, Xiao-Ping Xie, Wen-Sheng Liu, Jia-Xin Zheng, Gui-Fu Dai, Hong-Min Liu, Long-Hua Liu, Yi-Bo Liang
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 10 Pg. 2388-91 (May 15 2014) ISSN: 1464-3405 [Electronic] England
• PMID: 24745970 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antiviral Agents

Topics

• Animals
• Antiviral Agents (chemical synthesis, pharmacology)
• Cattle
• Diarrhea Viruses, Bovine Viral (drug effects)
• Disease Models, Animal
• Drug Design
• Hepacivirus (drug effects)