Effect of vitamin D-binding protein genotype on the development of asthma in children.

Abstract

BACKGROUND:

Potential vitamin D-related influences on inflammatory diseases such as asthma are controversial, including the suggestion that vitamin D insufficiency is associated with increased asthma morbidity. Vitamin D-binding protein transports vitamin D metabolites in the circulation. Single nucleotide polymorphisms in the GC gene encoding vitamin D-binding protein are associated with circulating vitamin D metabolite levels in healthy infants and toddlers.

OBJECTIVE:

To test the hypothesis that GC single nucleotide polymorphisms encoding the D432E and T436K variants predict subsequent development of asthma in healthy children.

METHODS:

A retrospective medical record review was performed to determine the development of asthma in 776 children in whom GC genotype, vitamin D-binding protein concentration, and circulating 25-hydroxyvitamin D had been determined at 6 to 36 months of age. Demographic and detailed current clinical data were collected and criteria for asthma were recorded.

RESULTS:

GC genotype was available for 463 subjects. After an initial analysis of all subject data, the analysis was limited to the predominant Hispanic population (72.1%) to minimize potential confounding effects of ethnicity. Asthma was diagnosed in 87 children (26%). Subjects with the GC genotype encoding the ET/ET (Gc1s/Gc1s) variant had lower odds of developing asthma, representing a protective effect compared with subjects with the DT/DT (Gc1f/Gc1f) variant.

CONCLUSION:

In the Hispanic population of inner-city New Haven, Connecticut, the ET/ET (Gc1s/Gc1s) genotype of vitamin D-binding protein might confer protection against the development of asthma compared with the wild-type genotype DT/DT (Gc1f/Gc1f).

• Authors: Aledie Navas-Nazario, Fang Yong Li, Veronika Shabanova, Pnina Weiss, David E C Cole, Thomas O Carpenter, Alia Bazzy-Asaad
• Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Ann Allergy Asthma Immunol) Vol. 112 Issue 6 Pg. 519-24 (Jun 2014) ISSN: 1534-4436 [Electronic] United States
• PMID: 24745702 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Calcitriol
• Vitamin D-Binding Protein
• Vitamin D
• 25-hydroxyvitamin D
• Cytochrome P450 Family 2
• CYP2R1 protein, human
• Cholestanetriol 26-Monooxygenase

Topics

• Asthma (genetics)
• Child, Preschool
• Cholestanetriol 26-Monooxygenase (genetics)
• Connecticut
• Cytochrome P450 Family 2
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Hispanic or Latino (genetics)
• Humans
• Infant
• Male
• Polymorphism, Single Nucleotide
• Receptors, Calcitriol (genetics)
• Retrospective Studies
• Vitamin D (analogs & derivatives, blood, genetics, therapeutic use)
• Vitamin D-Binding Protein (blood, genetics)