[A case of curatively resected sigmoid colon cancer after mFOLFOX6 plus panitumumab neoadjuvant chemotherapy].

Abstract

A 54-year-old man with residual urine, abdominal pain, and a high fever was diagnosed with KRAS wild-type sigmoid colon cancer with urinary bladder invasion. Considering the difficulty of curative resection, we first performed an ileostomy. Remarkable tumor regression was indicated by computed tomography(CT)and colonoscopy after 3 courses of mFOLFOX6 plus panitumumab. A sigmoidectomy and partial cystectomy were performed with a curative intent. Six courses of XELOX adjuvant chemotherapy were administered, and no recurrence has been observed for 9 months. mFOLFOX6 plus panitumumab might be an effective preoperative chemotherapy for patients with locally advanced KRAS wild-type colon cancer.

• Authors: Kiyoshi Yoshikawa, Hirofumi Kuwata, Yoshikatsu Nakahata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 3 Pg. 399-401 (Mar 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 24743293 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Organoplatinum Compounds
• Panitumumab
• Leucovorin
• Fluorouracil

Topics

• Antibodies, Monoclonal (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Invasiveness
• Neoplasm Staging
• Organoplatinum Compounds (administration & dosage)
• Panitumumab
• Sigmoid Neoplasms (drug therapy, pathology, surgery)