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[Clinical evaluation of lapatinib therapy in metastatic breast cancer using the Bayes meta-analysis].

Abstract
The efficacy of treatments involving lapatinib for patients with metastatic breast cancers was evaluated in a Bayesian metaanalysis of published data from randomized controlled clinical trials. Four randomized controlled trials including 2,708 patients met the inclusion criteria. Among these patients, 568 were positive for the human epidermal growth factor receptor 2(HER2). The clinical benefit rate(CBR)for HER2-positive patients was the primary outcome of the analysis, and the overall survival(l OS) and the number needed to treat(NNT)were the secondary outcomes of the reported meta-analysis. The Bayesian metaanalysis was conducted according to the Markov-chain Monte-Carlo technique in WinBUGS. The CBR for HER2-positive patients was significantly improved(odds ratio[OR]: 2.281, 95% confidence interval[CI]: 1.490-3.628), whereas no statistically significant improvement was seen in the overall patient CBR(OR: 1.559, 95% CI: 0.768-3.238). The OS hazard ratio (HR)and NNT for the CBR were also estimated for HER2-positive patients. The difference in the OS HR was not statistically significant(HR: 0.789, 95% CI: 0.556-1.086)for HER2-positive patients. The improvement in the NNT for the CBR was statistically significant(NNT 5.164, 95% CI: 3.803-8.723)for HER2-positive patients.
AuthorsTadao Inoue, Tomokazu Iyoda, Wataru Yamamoto, Yoshio Uetsuka
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 3 Pg. 347-52 (Mar 2014) ISSN: 0385-0684 [Print] Japan
PMID24743281 (Publication Type: English Abstract, Journal Article, Meta-Analysis)
Chemical References
  • Antineoplastic Agents
  • Quinazolines
  • lapatinib
  • ERBB2 protein, human
  • Receptor, ErbB-2
Topics
  • Antineoplastic Agents (therapeutic use)
  • Bayes Theorem
  • Breast Neoplasms (chemistry, drug therapy, pathology)
  • Humans
  • Neoplasm Metastasis
  • Quinazolines (therapeutic use)
  • Randomized Controlled Trials as Topic
  • Receptor, ErbB-2 (analysis)
  • Treatment Outcome

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