Abstract | OBJECTIVES: METHODS: SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. RESULTS: Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. CONCLUSION:
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Authors | Lei Huang, Jun Cao |
Journal | Oxidative medicine and cellular longevity
(Oxid Med Cell Longev)
Vol. 2014
Pg. 248786
( 2014)
ISSN: 1942-0994 [Electronic] United States |
PMID | 24738018
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Drugs, Chinese Herbal
- Protective Agents
- Shen-Fu
- Transcription Factor RelA
- Malondialdehyde
- Peroxidase
- Lipase
- Amylases
- Glutathione
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Topics |
- Acute Disease
- Amylases
(blood)
- Animals
- Cytokines
(blood)
- Disease Models, Animal
- Drugs, Chinese Herbal
(administration & dosage, pharmacology, therapeutic use)
- Glutathione
(metabolism)
- Injections
- Lipase
(blood)
- Male
- Malondialdehyde
(metabolism)
- Pancreas
(metabolism, pathology)
- Pancreatitis
(blood, chemically induced, drug therapy)
- Peroxidase
(metabolism)
- Protective Agents
(administration & dosage, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Transcription Factor RelA
(metabolism)
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