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The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.

AbstractOBJECTIVES:
In the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.
METHODS:
SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.
RESULTS:
Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.
CONCLUSION:
Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.
AuthorsLei Huang, Jun Cao
JournalOxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2014 Pg. 248786 ( 2014) ISSN: 1942-0994 [Electronic] United States
PMID24738018 (Publication Type: Journal Article)
Chemical References
  • Cytokines
  • Drugs, Chinese Herbal
  • Protective Agents
  • Shen-Fu
  • Transcription Factor RelA
  • Malondialdehyde
  • Peroxidase
  • Lipase
  • Amylases
  • Glutathione
Topics
  • Acute Disease
  • Amylases (blood)
  • Animals
  • Cytokines (blood)
  • Disease Models, Animal
  • Drugs, Chinese Herbal (administration & dosage, pharmacology, therapeutic use)
  • Glutathione (metabolism)
  • Injections
  • Lipase (blood)
  • Male
  • Malondialdehyde (metabolism)
  • Pancreas (metabolism, pathology)
  • Pancreatitis (blood, chemically induced, drug therapy)
  • Peroxidase (metabolism)
  • Protective Agents (administration & dosage, pharmacology, therapeutic use)
  • Rats
  • Rats, Sprague-Dawley
  • Transcription Factor RelA (metabolism)

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