Abstract | INTRODUCTION: The natural history of pelvic organ prolapse (POP) is poorly understood. We investigated the prevalence and risk factors of postnatal POP in premenopausal primiparous women and the associated effect of mode of delivery. METHODS: We conducted a prospective cohort study in a tertiary teaching hospital attending 9,000 deliveries annually. Collagen-diseases history and clinical assessment was performed in 202 primiparae at ≥ 1 year postnatally. Assessment included Pelvic Organ Prolapse Quantification (POP-Q) system, Beighton mobility score, 2/3D-transperineal ultrasound (US) and quantification of collagen type III levels. Association with POP was assessed using various statistical tests, including logistic regression, where results with p < 0.1 in univariate analysis were included in multivariate analysis. RESULTS: CONCLUSIONS: Mild to moderate POP has a very high prevalence in premenopausal primiparous women. There is a significant association between POP, collagen levels, history of collagen disease and childbirth-related pelvic floor trauma. These findings support a congenital contribution to POP etiology, especially for uterine prolapse; however, pelvic trauma seems to play paramount role. CS is significantly protective against some types of prolapse only.
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Authors | C M Durnea, A S Khashan, L C Kenny, U A Durnea, M M Smyth, B A O'Reilly |
Journal | International urogynecology journal
(Int Urogynecol J)
Vol. 25
Issue 11
Pg. 1463-70
(Nov 2014)
ISSN: 1433-3023 [Electronic] England |
PMID | 24737300
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Asthma
(epidemiology)
- Cesarean Section
- Collagen Type III
(blood)
- Female
- Humans
- Intervertebral Disc Displacement
(epidemiology)
- Joint Instability
(epidemiology)
- Middle Aged
- Muscle, Skeletal
(injuries)
- Parity
- Pelvic Organ Prolapse
(epidemiology, etiology)
- Premenopause
- Prevalence
- Prospective Studies
- Risk Factors
- Surveys and Questionnaires
- Varicose Veins
- Young Adult
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