[Experimental study of histamine-liberating properties of eremomycin].

Abstract

Eremomycin, a new glycopeptide antibiotic showed the same as ristomycin, polymyxins B and M and kanamycin histamine liberating properties. Liberation of endogenic histamine induced destructive lesions on the mucosa of the gastrointestinal tract. The most pronounced lesions were observed after intraperitoneal administration of the antibiotic. When eremomycin was administered intravenously or subcutaneously the affection of the gastrointestinal tract epithelium was less pronounced. After subplantar administration of the antibiotics pad edema in albino rats was observed. The most pronounced edema was after the use of ristomycin and the polymyxins. After the use of eremomycin and kanamycin it was at the average 2 times less pronounced. Preliminary administration of dimedrol decreased intensity of the pad edema induced by the antibiotics.

• Authors: S T Filippos'iants, L A Shevniuk
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 34 Issue 3 Pg. 209-12 (Mar 1989) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe izuchenie gistaminosvobozhdaiushchikh svoĭstv éremomitsina.
• PMID: 2473716 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Glycopeptides
• eremomycin

Topics

• Animals
• Anti-Bacterial Agents
• Drug Hypersensitivity (complications)
• Edema (chemically induced)
• Gastrointestinal Hemorrhage (chemically induced)
• Glycopeptides (administration & dosage, adverse effects)
• Hindlimb
• Histamine Release (drug effects)
• Hyperemia (chemically induced)
• Hypersensitivity, Immediate (chemically induced)
• Injections, Intraperitoneal
• Injections, Intravenous
• Injections, Subcutaneous
• Rats