Antiretroviral drug expenditure, pricing and judicial demand: an analysis of federal procurement data in Brazil from 2004-2011.

Previous studies have described expenditures for antiretroviral (ARV) medicines in Brazil through 2005. While prior studies examined overall expenditures, they have not have analyzed drug procurement data in order to describe the role of court litigation on access and pricing.
ARV drug procurement from private sector sources for the years 2004-2011 was obtained through the general procurement database of the Brazilian Federal Government (SIASG). Procurement was measured in Defined Daily Doses (DDD) per 1000 persons-under-treatment per day. Expenditures and price per DDD were calculated and expressed in U.S. Dollars. Justifications for ARV purchases were examined in order to determine the relationship between health litigation and incorporation into Brazil's national treatment guidelines.
Drug procurement of ARVs from private sources underwent marked expansion in 2005, peaked in 2009, and stabilized to 2008 levels by 2011. Expenditures followed procurement curves. Medications which were procured for the first time after 2007 cost more than medicines which were introduced before 2007. Judicial actions initially resulted in purchases of newer medications for a select number of patients in Brazil but ultimately expanded availability to a larger population through incorporation into the national treatment guidelines.
Drug procurement and expenditures for ARVs in Brazil varied between 2004-2011. The procurement of some drugs from the private sector ceased after public manufacturers started producing them locally. Judicial demand has resulted in the incorporation of newer drugs into the national treatment guidelines. In order for the AIDS treatment program to remain sustainable, efforts should be pursued to reduce prices through generic drugs, price negotiation and other public health flexibilities such as compulsory licensing.
AuthorsJing Luo, Maria A Oliveira, Mariana B C Ramos, Aurélio Maia, Claudia G S Osorio-de-Castro
JournalBMC public health (BMC Public Health) Vol. 14 Pg. 367 ( 2014) ISSN: 1471-2458 [Electronic] England
PMID24735589 (Publication Type: Journal Article)
Chemical References
  • Anti-HIV Agents
  • Drugs, Generic
  • Adult
  • Anti-HIV Agents (economics, therapeutic use)
  • Brazil
  • Commerce
  • Drug Costs (legislation & jurisprudence)
  • Drugs, Generic (economics)
  • HIV Infections (drug therapy, economics)
  • Health Expenditures
  • Humans
  • Negotiating
  • Private Sector (economics)
  • United States

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