Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

Abstract

The expression of HLA-A,B,C antigens and lymphocyte function-associated antigen 3 in human colorectal adenomas and adenocarcinomas was studied by immunohistochemistry. None of 10 adenomas and only 1 of 30 carcinomas had lost expression of all HLA-A,B,C molecules. On the other hand, focal loss of an HLA-B product was seen in 2 of the adenomas, and complete losses of tumor cell HLA-A2 (in 7 of 13 cases), HLA-Bw4 (in 4 of 13 cases), and HLA-A3 (in 1 of 6 cases) were seen in the carcinomas. No complete losses of HLA-A1 (in 6 cases) or HLA-Bw6 (in 22 cases) occurred in the carcinomas. In addition, 1 of 20 adenocarcinomas totally lacked lymphocyte function-associated antigen 3. Because a loss of tumor cell HLA-A,B,C antigen or lymphocyte function-associated antigen 3 could be selected for through an advantage in escape from cytotoxic T-lymphocyte attack, our results suggest that immunoselection may be a more important mechanism in tumor progression than has previously been assumed.

• Authors: M E Smith, S G Marsh, J G Bodmer, K Gelsthorpe, W F Bodmer
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 86 Issue 14 Pg. 5557-61 (Jul 1989) ISSN: 0027-8424 [Print] United States
• PMID: 2473473 (Publication Type: Journal Article)

Chemical References

• Antigens, Surface
• CD58 Antigens
• HLA-A Antigens
• HLA-B Antigens
• HLA-C Antigens
• Membrane Glycoproteins

Topics

• Adenocarcinoma (genetics, immunology, pathology)
• Adenoma (genetics, immunology, pathology)
• Alleles
• Antigens, Surface (genetics)
• CD58 Antigens
• Colonic Neoplasms (genetics, immunology, pathology)
• Genes, MHC Class II
• HLA-A Antigens (analysis, genetics)
• HLA-B Antigens (analysis, genetics)
• HLA-C Antigens (analysis, genetics)
• Humans
• Immunoenzyme Techniques
• Membrane Glycoproteins (genetics)
• Tumor Cells, Cultured (immunology)