Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome.

Abstract

Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality. We analyzed the incidence, risk factors, and prognosis of VRIs in a cohort of transplanted patients. More frequent viruses were human coronavirus and human rhinovirus followed by flu-like viruses and adenovirus. Risk factors for death were lymphocytopenia and high steroid dosage.

• Authors: Alice Wolfromm, Raphael Porcher, Jérome Legoff, Régis Peffault de Latour, Aliénor Xhaard, Flore Sicre de Fontbrune, Patricia Ribaud, Anne Bergeron, Gérard Socié, Marie Robin
• Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 20 Issue 8 Pg. 1238-41 (Aug 2014) ISSN: 1523-6536 [Electronic] United States
• PMID: 24732781 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Cohort Studies
• Female
• Hematopoietic Stem Cell Transplantation (adverse effects, mortality)
• Humans
• Incidence
• Male
• Middle Aged
• Multiplex Polymerase Chain Reaction (methods)
• Respiratory Tract Infections (diagnosis, etiology, virology)
• Transplantation Conditioning (adverse effects, mortality)
• Transplantation, Homologous (adverse effects, mortality)
• Treatment Outcome
• Young Adult