Abstract |
To determine the influence of buthionine sulfoximine (BSO) on boron biodistribution after sulfhydryl borane (BSH) administration for boron neutron capture therapy, the effectiveness of the combination of BSO with sulfhydril- (BSH) and non-sulfhydril (B12H12 and BNH3) boron compounds, and the interval between BSO and BSH administration, the retention of boron in tissues have been evaluated using a 9L rat tumor model. Simultaneous administration of BSH and BSO showed significantly higher boron accumulation compared to that without BSO, however there was no difference in tissue boron level between B12H12 and BNH3 administration with BSO or without BSO. The longer interval (6h) between BSH and BSO administration related to the highest boron concentration in the brain and subcutaneous tumors compared to shorter intervals (0.5, 3h). Boron concentration in subcutaneous and brain tumors was maintained for 6 and 12h after the administration of BSH following BSO pretreatment.
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Authors | F Yoshida, T Yamamoto, K Nakai, A Zaboronok, M Matsuda, H Akutsu, E Ishikawa, M Shirakawa, A Matsumura |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 88
Pg. 86-8
(Jun 2014)
ISSN: 1872-9800 [Electronic] England |
PMID | 24731546
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Borohydrides
- Sulfhydryl Compounds
- mercaptoundecahydrododecaborate
- Buthionine Sulfoximine
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Topics |
- Animals
- Borohydrides
(administration & dosage, pharmacokinetics)
- Boron Neutron Capture Therapy
(methods)
- Brain Neoplasms
(metabolism, radiotherapy)
- Buthionine Sulfoximine
(administration & dosage, pharmacokinetics)
- Drug Synergism
- Male
- Metabolic Clearance Rate
(drug effects)
- Organ Specificity
(drug effects)
- Premedication
(methods)
- Rats
- Rats, Inbred F344
- Sulfhydryl Compounds
(administration & dosage, pharmacokinetics)
- Tissue Distribution
(drug effects)
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