Abstract | BACKGROUND: CASE: The patient's karyotype from blood lymphocytes was a mosaic of 45,XO/ 46,XX. Menarche and sexual development were normal. Her menstrual cycle had been regular for one year, but then became noticeably irregular. At age 26 she was referred to our hospital after bleeding for almost 1 year. An endometrial adenocarcinoma was detected during performance of diagnostic endometrial curettage. A total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was conducted. The final histological diagnosis was endometrial adenocarcinoma, Grade 1, pT1a N0 M0. Fluorescence in situ hybridization analysis of the right and left ovaries revealed a mosaic karyotype of 45,XO/ CONCLUSION: Previous reports regarding Turner's syndrome detected spontaneous menstruation in only 16% of patients; however, spontaneous menstruation was observed in 8 of 10 (80%) Turner's syndrome cases that developed endometrial carcinoma without receiving regular hormone therapy (p < 0.0001). Hormone therapy may be indicated for an irregular menstrual cycle in Turner's syndrome patients.
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Authors | Naoko Sasamoto, Yutaka Ueda, Kyoka Amemiya, Takayuki Enomoto, Eiichi Morii, Kazushige Adachi |
Journal | The Journal of reproductive medicine
(J Reprod Med)
2014 Mar-Apr
Vol. 59
Issue 3-4
Pg. 177-80
ISSN: 0024-7758 [Print] United States |
PMID | 24724228
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adenocarcinoma
(complications, diagnosis, surgery)
- Adult
- Endometrial Neoplasms
(complications, diagnosis, surgery)
- Female
- Humans
- Hysterectomy
- Karyotype
- Lymph Node Excision
- Menstruation
- Mosaicism
- Ovariectomy
- Salpingectomy
- Turner Syndrome
(complications, genetics, physiopathology)
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