A case of oxaliplatin-induced immune-mediated thrombocytopenia.

Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.
AuthorsSeong Eun Suh, Moon Ju Jang, So Young Chong, Richard H Aster, Brian R Curtis, Doyeun Oh
JournalBlood research (Blood Res) Vol. 49 Issue 1 Pg. 61-4 (Mar 2014) ISSN: 2287-979X [Print] Korea (South)
PMID24724069 (Publication Type: Journal Article)

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