HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case.

Abstract
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.
AuthorsAaron E Yancoskie, Chandrika Sreekantaiah, Jessy Jacob, Amanda Rosenberg, Morris Edelman, Cristina R Antonescu, John E Fantasia
JournalOral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 118 Issue 4 Pg. e115-8 (Oct 2014) ISSN: 2212-4411 [Electronic] United States
PMID24721473 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Calmodulin-Binding Proteins
  • EWSR1 protein, human
  • RNA-Binding Proteins
Topics
  • Adenocarcinoma, Clear Cell (diagnosis, genetics, pathology, surgery)
  • Biopsy
  • Calmodulin-Binding Proteins (genetics)
  • Cone-Beam Computed Tomography
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Female
  • Gene Rearrangement
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Mandibular Neoplasms (diagnosis, genetics, pathology, surgery)
  • Middle Aged
  • Odontogenic Tumors (diagnosis, genetics, pathology, surgery)
  • RNA-Binding Proteins (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: