[Evaluation of mycobacterial infections using 18F-fluorodeoxyglucose-positron emission tomography: results of nine cases].

Abstract

18F-fluorodeoxyglucose-positron emission tomography (FDG-PET/CT) is a useful technique for distinguishing malignant and benign lesions, although the occurrence of false-positive results in cases involving benign lesions is possible. We evaluated nine patients with mycobacterial infections who underwent FDG-PET/CT from April 2008 to July 2010. FDG-PET/CT was performed 1-2h (during the early and late phases) after administration of FDG at a dose of 185 MBq/individual after fasting for at least 5h. Out of the nine patients, four were diagnosed with pulmonary nonmycobacterium tuberculosis, two with pulmonary tuberculosis, two with tuberculous lymphadenopathy, and one with pleural tuberculoma. All patients had a maximum standardized uptake value (SUV(max)) of > 2.5, and the SUV(max) increased from the early to the late phase. One lesion that occurred due to tuberculous pleurisy after treatment demonstrated high FDG uptake, similar to the other cases. It is difficult to distinguish mycobacterial infections from malignant diseases using FGD-PET alone; hence, the use of high-resolution CT and bacteriological tests is required for diagnosis and distinction.

• Authors: Hironori Uruga, Makiko Ishihara, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Takeshi Fujii, Atsuko Kurosaki, Kazuma Kishi
• Journal: Kekkaku : [Tuberculosis] (Kekkaku) Vol. 89 Issue 2 Pg. 39-43 (Feb 2014) ISSN: 0022-9776 [Print] Japan
• PMID: 24716357 (Publication Type: English Abstract, Journal Article)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Aged
• Aged, 80 and over
• Female
• Fluorodeoxyglucose F18
• Humans
• Male
• Middle Aged
• Mycobacterium Infections, Nontuberculous (diagnosis)
• Positron-Emission Tomography
• Tomography, X-Ray Computed
• Tuberculosis (diagnosis)
• Tuberculosis, Pulmonary (diagnosis)