Introduction. Primary
signet ring cell carcinoma (SRCC) of the lung is a very
rare disease. We describe a new case of primary SRCC of the lung with cerebellar
metastasis, which responded well to the therapeutic approach with
cisplatin and
docetaxel. Case Report. A 41-year-old female patient (nonsmoker) was consulted to our oncology outpatient clinic after cerebellar
metastasectomy. The histopathological diagnosis was SRCC
metastasis. The primary
tumor was unknown. The PET-CT imaging showed a hypermetabolic mass in the right middle lobe of the lung and hypermetabolic mediastinal lymph node stations. Oesophagogastroduodenoscopy and colonoscopy showed no evidence of gastrointestinal system
tumor. The clinical diagnosis of primary SRCC of the lung was made and the administration of six rounds of
cisplatin and
docetaxel treatment was planned. After the
chemotherapy the PET-CT scan to evaluate the
therapy response showed full metabolic regression of the primary
tumor and the mediastinal lymph nodes. There was no evidence of new
metastasis. Conclusion. Primary SRCC of the lung is a very
rare disease with poor prognosis. There are not many cases in literature and no standardized
chemotherapy protocols.
Cisplatin and
docetaxel may be a good treatment option.