Abstract | BACKGROUND: METHODS: A decision tree model was used to compare treatment with dantrolene to a supportive care-only strategy. Model assumptions include the incidence of MH, MH case fatality with dantrolene treatment and with supportive care-only. Sensitivity analyses were performed to assess the robustness of the estimated cost-effectiveness. RESULTS: The estimated annual number of MH events in ambulatory surgery centers in the United States was 47. The incremental effectiveness of dantrolene compared with supportive care was 33 more lives saved per year. The incremental cost-effectiveness ratio was $196,320 (in 2010 dollars) per life saved compared with a supportive care strategy. Sensitivity analysis showed that the results were robust for the plausible range of all variables and assumptions tested. CONCLUSION: The results of this analysis suggest that stocking dantrolene for the treatment of MH in ambulatory surgery centers as recommended by the Malignant Hyperthermia Association of the United States is cost-effective when compared with the estimated values of statistical life used by U.S. regulatory agencies.
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Authors | Taiwo Aderibigbe, Barbara H Lang, Henry Rosenberg, Qixuan Chen, Guohua Li |
Journal | Anesthesiology
(Anesthesiology)
Vol. 120
Issue 6
Pg. 1333-8
(Jun 2014)
ISSN: 1528-1175 [Electronic] United States |
PMID | 24714119
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Ambulatory Surgical Procedures
(economics, methods)
- Anesthesia, General
(adverse effects)
- Cost-Benefit Analysis
- Dantrolene
(administration & dosage, economics)
- Decision Trees
- Humans
- Malignant Hyperthermia
(drug therapy, epidemiology)
- Surgicenters
(economics, methods)
- Treatment Outcome
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