[A new clinical trial in intravesical chemotherapy with instillation of peplomycin preparation as an emulsion in hydroxypropylcellulosum--preliminary study of patients with bladder tumor].

Abstract

A new peplomycin (PEP) preparation was employed as an emulsion form in hydroxypropylcellulosum (HPC), which is familiar to have a liniment effect with a strong affinity to mucosa of the organ, in the management of 6 patients with bladder tumors. This emuled PEP in HPC (HPC-PEP) was instillated and thereafter, maintained for at least 2 hours at the frequency of once a week. All 6 patients had histopathologically confirmed T1 or T2 transitional cell carcinoma on biopsied specimen. The histological grading of the tumors were divided to 2 in G1, 3 in G2, and 1 in G3 of transitional cell carcinoma. The instillated agent was prepared from the mixture of 15 ml of 6% HPC and 90 mg PEP in 15 ml saline prior to use. A response to this treatment was evaluated primarily by cystoscopic findings and urine cytology 7 days after the instillation. In the present study, the beneficial effects of this treatment were briefly segregated into 4 categories as follows: excellent, good, fair and no responses were referred respectively to as complete eradication of visible tumor with negative urine cytology, a complete disappearance of the primary tumor with a persistent positive cytology, regression of the tumor size and no change of the primary tumor with sustained positive cytology. According to this estimation, 6 patients were categorized to 1 in excellent, 2 in good, 2 in fair and 1 in no responses to this new therapeutic preparation. Furthermore, urinary and serum levels of PEP were determined daily for 7 days after the instillation.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: M Asakawa, T Maekawa, K Mori, Y Ozaki, A Horii, R Yasumoto, S Nishio, M Maekawa
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 35 Issue 1 Pg. 39-42 (Jan 1989) ISSN: 0018-1994 [Print] Japan
• PMID: 2471398 (Publication Type: Journal Article)

Chemical References

• Emulsions
• Pharmaceutical Vehicles
• Bleomycin
• Peplomycin
• Cellulose
• hydroxypropylcellulose

Topics

• Administration, Intravesical
• Aged
• Aged, 80 and over
• Bleomycin (administration & dosage)
• Carcinoma, Transitional Cell (drug therapy)
• Cellulose (administration & dosage, analogs & derivatives)
• Emulsions
• Female
• Humans
• Male
• Peplomycin
• Pharmaceutical Vehicles
• Urinary Bladder Neoplasms (drug therapy)