Estradiol valerate plus dienogest versus ethinylestradiol plus levonorgestrel for the treatment of primary dysmenorrhea.

To demonstrate the superiority of estradiol valerate plus dienogest (E(2)V/DNG) over ethinylestradiol plus levonorgestrel (EE/LNG) in reducing the number of days with dysmenorrheic pain among women with primary dysmenorrhea.
In a phase IIIb trial conducted at 44 centers worldwide between April 2009 and November 2010, otherwise healthy women aged 14-50 years requesting contraception were randomized to daily oral administration of E(2)V/DNG (n = 253) or EE/LNG (n = 254) for three 28-daycycles. The primary efficacy variable was number of days with dysmenorrheic pain, the category of which (none, mild, moderate, severe) was self-assessed on a daily basis (irrespective of menstrual bleeding status) and recorded on diary cards. Notably, the women documented their pain as they experienced it before taking any (permitted) rescue medication.
Overall, 217 and 209 women receiving E(2)V/DNG and EE/LNG, respectively, completed the study. The mean ± SD change from baseline in number of days with dysmenorrheic pain was -4.6 ± 4.6 days and -4.2 ± 4.2 days for the E(2)V/DNG and EE/LNG groups, respectively (P = 0.34).
Both E(2)V/DNG and EE/LNG led to considerable relief of dysmenorrheic complaints among women with primary dysmenorrhea, decreasing the number of days with dysmenorrheic pain from baseline to a similar extent. ClinicalTrials.gov:NCT00909857.
AuthorsFelice Petraglia, Susanne Parke, Marco Serrani, Uwe Mellinger, Thomas Römer
JournalInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 125 Issue 3 Pg. 270-4 (Jun 2014) ISSN: 1879-3479 [Electronic] Ireland
PMID24713413 (Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 International Federation of Gynecology and Obstetrics. All rights reserved.
Chemical References
  • estradiol valerate-dienogest
  • ethinyl estradiol, levonorgestrel drug combination
  • Ethinyl Estradiol
  • Estradiol
  • Levonorgestrel
  • Nandrolone
  • Adolescent
  • Adult
  • Double-Blind Method
  • Dysmenorrhea (drug therapy)
  • Estradiol (analogs & derivatives, therapeutic use)
  • Ethinyl Estradiol (therapeutic use)
  • Female
  • Humans
  • Levonorgestrel (therapeutic use)
  • Middle Aged
  • Nandrolone (analogs & derivatives, therapeutic use)
  • Time Factors
  • Treatment Outcome
  • Young Adult

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