Abstract |
Chronic treatment with selective alpha 1-inhibitors has a beneficial impact on plasma lipids and arterial pressure. To study the effect of selective alpha 1-inhibition on atherogenesis, gerbils and hamsters were fed rodent chow containing 0.2% cholesterol and 10% coconut oil (by weight). One group of each species received the selective alpha 1-inhibitor doxazosin (gerbil, 17 mg/kg/day; hamster, 11 mg/kg/day) in the diet. In gerbils treated for 6 weeks with doxazosin, plasma total cholesterol fell by 39% and very-low-density lipoprotein (VLDL) plus low-density lipoprotein ( LDL) cholesterol by 52% compared with control levels. Plasma triglyceride and high-density lipoprotein ( HDL) cholesterol were unaffected. In hamsters treated with doxazosin for 6 weeks, plasma total cholesterol, VLDL plus LDL cholesterols, and triglyceride were reduced by approximately 40% compared with hyperlipidemic controls. HDL cholesterol, mean arterial pressure, and heart rate were not significantly altered. Using en face preparations of the hamster aortic arch, intimal macrophage-derived foam cells were quantitated. Compared with controls, doxazosin reduced the number of intimal foam cells/mm2 by 71%. We suggest that selective alpha 1-inhibition reduces foam cell accumulation by lowering plasma lipids and/or by a direct effect on the arterial wall.
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Authors | M C Kowala, R J Nicolosi |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 13 Suppl 2
Pg. S45-9; discussion S49
( 1989)
ISSN: 0160-2446 [Print] United States |
PMID | 2471015
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Antagonists
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Cholesterol
- Doxazosin
- Prazosin
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Topics |
- Adrenergic alpha-Antagonists
(pharmacology)
- Animals
- Arteriosclerosis
(etiology)
- Blood Pressure
(drug effects)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Doxazosin
- Female
- Foam Cells
(drug effects)
- Gerbillinae
(metabolism)
- Heart Rate
(drug effects)
- Male
- Prazosin
(analogs & derivatives, pharmacology)
- Triglycerides
(blood)
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