Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

According to the Chinese, European, Iranian and Indian traditional medicines, oleo gum resin of Ferula assa-foetida (asafoetida) has therapeutic effects on different kinds of diseases. Some of these effects are related to the diseases of nervous system such as hysteresis and convulsion. In recent studies, some anti-epileptic and neuroprotective roles were also considered for it and we examined its possible role on treatment of peripheral neuropathy.

MATERIAL AND METHODS:

in vitro studies were carried out to identify the response of isolated sciatic nerves to different concentrations of oleo gum resin of asafoetida solved in Lock׳s solution. Then, in vivo studies were conducted to evaluate its effect on amelioration of peripheral neuropathy in mice. Peripheral neuropathy was induced by intraperiotoneal injection of high doses of pyridoxine in adult Balb/c male mice. Tail flick tests were performed to identify the incidence of neuropathy in animals. After 10 days treatment with asafoetida, the efficiency of treatment was assessed by behavioral, electrophysiological and histological studies.

RESULTS:

in vitro experiments confirmed that incubating the nerves in aqueous extract of oleo gum rein of asafoetida increased the amplitude and decreased the latent period of nerve compound action potential (CAP). Nerve conduction velocity (NCV) and amplitude of CAP also improved in asafoetida treated animals. Histological and behavioral studies showed that asafoetida was able to facilitate the healing process in peripheral nerves.

CONCLUSIONS:

in vitro experiments showed that asafoetida is a nerve stimulant and its administration in neuropathic mice exerted neuroprotecting effects through stimulating axonal regeneration and remyelination and decrement of lymphocyte infiltration.

• Authors: Farshad Homayouni Moghadam, Maryam Dehghan, Ehsan Zarepur, Reyhaneh Dehlavi, Fatemeh Ghaseminia, Shima Ehsani, Golnaz Mohammadzadeh, Kazem Barzegar
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 154 Issue 1 Pg. 183-9 (May 28 2014) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 24709312 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Neuroprotective Agents
• Resins, Plant
• Pyridoxine

Topics

• Action Potentials (drug effects)
• Animals
• Ferula
• In Vitro Techniques
• Male
• Mice, Inbred BALB C
• Neuroprotective Agents (pharmacology, therapeutic use)
• Peripheral Nervous System Diseases (chemically induced, drug therapy)
• Phytotherapy
• Pyridoxine
• Resins, Plant (pharmacology, therapeutic use)
• Sciatic Nerve (drug effects, physiology)