Ubiquinol improves symptoms in children with autism.

Abstract

BACKGROUND:

Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and aggression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism.

METHODS:

Twenty-four children, aged 3-6 years, with autism according to the DSM IV criteria and using CARS were included in the study. Concentrations of CoQ10-TOTAL, γ- and α-tocopherol, β-carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose 2 × 50 mg. Data on behavior of the children were collected from parents at the same time.

RESULTS:

Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in 12%), verbal communication (in 21%), playing games of children (in 42%), sleeping (in 34%), and food rejection (in 17%), with CoQ10-TOTAL plasma level above 2.5 μmol/L.

CONCLUSIONS:

Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ10-TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.

• Authors: Anna Gvozdjáková, Jarmila Kucharská, Daniela Ostatníková, Katarína Babinská, Dalibor Nakládal, Fred L Crane
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2014 Pg. 798957 ( 2014) ISSN: 1942-0994 [Electronic] United States
• PMID: 24707344 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Thiobarbituric Acid Reactive Substances
• Ubiquinone
• ubiquinol

Topics

• Antioxidants (metabolism)
• Autistic Disorder (blood, drug therapy, psychology)
• Behavior
• Binding Sites
• Child
• Child, Preschool
• Female
• Humans
• Male
• Thiobarbituric Acid Reactive Substances (metabolism)
• Ubiquinone (analogs & derivatives, metabolism, therapeutic use)