The secretion of large volumes of fluid into
cysts and changes in the structure and mobility of the cilia of the renal tubular epithelium can lead to nephromegaly. This in turn often causes a deterioration of kidney function and arterial
hypertension. In recent clinical studies,
somatostatin analogues have demonstrated efficacy in
isolated polycystic liver disease and, to a lesser extent, in
polycystic kidney disease. Since the publication of these clinical studies, several patients have been referred to us for
somatostatin analogue treatment. Here, we report our experience with 6 patients who were treated with
lanreotide autogel 120 mg every 4 weeks over 6, 12 or 18 months and were longitudinally followed using CT scans without
contrast agents, to evaluate the total bilateral kidney volume. We observed a mean decrease in volume of 4%, with mild to moderate side effects.