Varenicline is more effective in attenuating weight gain than nicotine patch 12 months after the end of smoking cessation therapy: an observational study in Japan.

Abstract

INTRODUCTION:

Although both varenicline and nicotine patch have a beneficial effect in controlling postcessation weight gain, it is not well known whether there is a difference in the effect.

METHODS:

We conducted a multi-institutional study on smoking cessation therapy (SCT) administered at 4 Japanese hospitals to compare the body weight change from the first session to 12 months after the end of SCT (at 60 weeks) between varenicline users (n = 307) and nicotine patch users (n = 45).

RESULTS:

The mean weight change from baseline to 12 months after the end of SCT was +0.94 kg (SD: 3.59) in varenicline users and +2.78 kg (SD: 4.88) in nicotine patch users (p = .003, by t test). In multivariate linear regression analysis, varenicline users gained significantly less weight than nicotine patch users (coefficient: -1.787, 95% CI = -2.98 to -0.59) with adjustment for success of quit smoking, age, sex, presence of comorbidity, body mass index at baseline, Fagerström Test for Nicotine Dependence, craving at the end of SCT, and nausea through the SCT.

CONCLUSION:

Our results indicated that varenicline is more effective in attenuating weight gain than nicotine patch in smokers who received Japanese SCT.

• Authors: Chie Taniguchi, Hideo Tanaka, Noriko Nakamura, Hideo Saka, Isao Oze, Hidemi Ito, Kazunobu Tachibana, Akihiro Tokoro, Yasuhiro Nozaki, Nobuyo Nakamichi, Hisataka Sakakibara
• Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (Nicotine Tob Res) Vol. 16 Issue 7 Pg. 1026-9 (Jul 2014) ISSN: 1469-994X [Electronic] England
• PMID: 24706051 (Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2014. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Benzazepines
• Nicotinic Agonists
• Quinoxalines
• Varenicline

Topics

• Asian People
• Benzazepines (therapeutic use)
• Body Mass Index
• Female
• Humans
• Japan
• Linear Models
• Male
• Middle Aged
• Multivariate Analysis
• Nicotinic Agonists (therapeutic use)
• Quinoxalines (therapeutic use)
• Smoking Cessation (methods)
• Tobacco Use Cessation Devices
• Varenicline
• Weight Gain