Cerebral palsy patients discovered dead during sleep: experience from a comprehensive tertiary pediatric center.

It is not uncommon for children with cerebral palsy (CP) to be discovered dead during sleep (DDDS); however, the factors associated with this pattern of mortality remain unknown. The current study aims to describe the mortality associated with children with CP from a single, tertiary care center who were DDDS.
A retrospective (case-only) design to examine proportionate mortality and patient characteristics and co-morbidities that may be related to children DDDS between 1993 and 2011.
There were 177 patients with CP whose deaths were reported to our institution during the study period, of which 19 were DDDS at home. The period proportionate mortality (PPM) was 114.5 per 1000. The average age at time of death was 17 years and 6 months (minimum, 6 years; maximum, 25 years). All but one of the DDDS patients had gastrointestinal feeding tubes, seizure disorders, respiratory disorders, and were non-ambulatory. Very importantly, our DDDS patients manifested clusters of respiratory disorders, namely recurrent aspiration pneumonia (10/19), asthma pneumonitis (4/19), food/vomitius inhalation (6/19), reactive airway disease (16/19), respiratory failure (14/19), chronic bronchitis (7/19), chronic obstructive lung disease (9/19), and nocturnal respiratory insufficiency (16/19).
Respiratory disorders, severe motor disability, seizures, and intellectual status are possible co-morbidities that may be associated with DDDS. There is a need for further study in order to understand what type of monitoring and care (if any) may help prevent DDDS related to these co-morbidities and sleep disorders/abnormalities.
AuthorsAli F Karatas, Elissa G Miller, Freeman Miller, Kirk W Dabney, Steven Bachrach, Justin Connor, Kenneth Rogers, Laurens Holmes Jr
JournalJournal of pediatric rehabilitation medicine (J Pediatr Rehabil Med) Vol. 6 Issue 4 Pg. 225-31 (Jan 1 2013) ISSN: 1875-8894 [Electronic] Netherlands
PMID24705657 (Publication Type: Journal Article)
  • Adolescent
  • Adult
  • Cerebral Palsy (mortality)
  • Child
  • Comorbidity
  • Female
  • Humans
  • Lung Diseases (epidemiology)
  • Male
  • Respiration Disorders (epidemiology)
  • Retrospective Studies
  • Risk Factors
  • Sleep
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: