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Therapeutic efficacy of antibiotic-loaded gelatin microsphere/silk fibroin scaffolds in infected full-thickness burns.

Abstract
Despite advances in burn treatment, burn infection remains a major cause of morbidity and mortality. In this study, an antibacterial silk fibroin (SF) scaffold for burn treatment was designed; gelatin microspheres (GMs) were impregnated with the antibiotic gentamycin sulfate (GS), and the GS-impregnated GMs were then embedded in a SF matrix to fabricate GS/GM/SF scaffolds. The developed GS/GM/SF scaffolds could serve as a dermal regeneration template in full-thickness burns. The average pore size and porosity of the GS/GM/SF scaffolds were 40-80 μm and 85%, respectively. Furthermore, the drug release rate of the scaffolds was significantly slower than that of either GS/GM or GS/SF scaffolds. And the composite scaffold exhibited stronger antimicrobial activities against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Hence, we evaluated the wound-healing effects and antibacterial properties of the GS/GM/SF scaffolds in a rat full-thickness burn infection model. Over 21 days, the GS/GM/SF scaffolds not only significantly reduced burn infection by P. aeruginosa but also accelerated the regeneration of the dermis and exhibited higher epithelialization rates than did GS/SF and SF scaffolds. Thus, GS/GM/SF scaffolds are potentially effective for treatment of full-thickness infected burns, and GS/GM/SF scaffolds are a promising therapeutic tool for severely burned patients.
AuthorsYong Lan, Weichang Li, Yanpeng Jiao, Rui Guo, Yi Zhang, Wei Xue, Yuanming Zhang
JournalActa biomaterialia (Acta Biomater) Vol. 10 Issue 7 Pg. 3167-76 (Jul 2014) ISSN: 1878-7568 [Electronic] England
PMID24704698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Silk
  • Gelatin
  • Fibroins
Topics
  • Animals
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Burns (drug therapy, therapy)
  • Fibroins
  • Gelatin (chemistry)
  • Male
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Microspheres
  • Rats
  • Rats, Sprague-Dawley
  • Silk (chemistry)
  • Spectroscopy, Fourier Transform Infrared
  • Tissue Scaffolds
  • Wound Healing

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