Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese.

Abstract

Inhibition of interleukin-23 (IL-23) signaling was reported to reduce AD pathology, and IL-23 receptor gene (IL23R) which encodes IL-23 receptor may represent a candidate susceptibility gene for AD. Here, we conducted a case-control association study to assess the effect of IL23R genetic polymorphisms on the risk of AD in a Northern Han Chinese population. Two tag functional single polymorphisms (SNPs), rs10889677 and rs1884444 were selected, and their associations with AD risk factors were assessed in 1133 AD patients and 1156 matched controls. Our association analysis showed that C allele of rs10889677 was significantly associated with decreased AD risk even after adjusting for age, gender, and apolipoprotein E gene (APOE) ɛ4 status. The G allele of rs1884444 polymorphism is significantly associated with a higher risk of AD in APOE ɛ4 carriers. Our results demonstrate that IL23R genetic polymorphisms are associated with AD in a Northern Han Chinese population.

• Authors: Ying Liu, Jin-Tai Yu, Wei Zhang, Yu Zong, Rui-Chun Lu, Jing Zhou, Lan Tan
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 271 Issue 1-2 Pg. 43-8 (Jun 15 2014) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 24703098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Apolipoproteins E
• IL23R protein, human
• Receptors, Interleukin

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (ethnology, genetics)
• Apolipoproteins E (genetics)
• Asian People (ethnology, genetics)
• China (ethnology)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Linkage Disequilibrium
• Male
• Multivariate Analysis
• Polymorphism, Single Nucleotide (genetics)
• Receptors, Interleukin (genetics)