Abstract |
Multidrug resistance (MDR) remains a major challenge for cancer treatment thus far. Free doxorubicin (DOX, one of the most widely used chemotherapy agents for cancer treatment) generally features a large value of resistant factor (RF), which is regarded as a significant parameter to assess therapeutic efficiency of cross-resistance. To address this issue, we herein present a kind of silicon nanowires (SiNWs)-based drug nanocarriers (SiNW-DOX), which is high-efficacy for treatment of drug-resistant cancer cells. Typically, drug-resistance cancer cells (e.g., MCF-7/ADR cells) can be significantly inhibited by the SiNWs-based nanocarriers, exhibiting ∼10% cell viability during 72-h incubation with the SiNWs-DOX (80 μg mL(-1) DOX), which is in sharp contrast to free DOX-treated cells preserving ∼40% cell viability. Remarkably, the RF value of SiNW-DOX is as low as ∼2.0, which is much better than that (∼300) of free DOX under the same experiment conditions. To the best of our knowledge, it is the lowest RF value ever reported by nanomaterials-based drug carriers (3.3-24.7).
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Authors | Fei Peng, Yuanyuan Su, Xiaoyuan Ji, Yiling Zhong, Xinpan Wei, Yao He |
Journal | Biomaterials
(Biomaterials)
Vol. 35
Issue 19
Pg. 5188-95
(Jun 2014)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 24702959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Drug Carriers
- Doxorubicin
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Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Doxorubicin
(chemistry, pharmacology)
- Drug Carriers
(chemistry)
- Drug Resistance, Neoplasm
- Humans
- MCF-7 Cells
- Nanowires
(chemistry)
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