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Doxorubicin-loaded silicon nanowires for the treatment of drug-resistant cancer cells.

Abstract
Multidrug resistance (MDR) remains a major challenge for cancer treatment thus far. Free doxorubicin (DOX, one of the most widely used chemotherapy agents for cancer treatment) generally features a large value of resistant factor (RF), which is regarded as a significant parameter to assess therapeutic efficiency of cross-resistance. To address this issue, we herein present a kind of silicon nanowires (SiNWs)-based drug nanocarriers (SiNW-DOX), which is high-efficacy for treatment of drug-resistant cancer cells. Typically, drug-resistance cancer cells (e.g., MCF-7/ADR cells) can be significantly inhibited by the SiNWs-based nanocarriers, exhibiting ∼10% cell viability during 72-h incubation with the SiNWs-DOX (80 μg mL(-1) DOX), which is in sharp contrast to free DOX-treated cells preserving ∼40% cell viability. Remarkably, the RF value of SiNW-DOX is as low as ∼2.0, which is much better than that (∼300) of free DOX under the same experiment conditions. To the best of our knowledge, it is the lowest RF value ever reported by nanomaterials-based drug carriers (3.3-24.7).
AuthorsFei Peng, Yuanyuan Su, Xiaoyuan Ji, Yiling Zhong, Xinpan Wei, Yao He
JournalBiomaterials (Biomaterials) Vol. 35 Issue 19 Pg. 5188-95 (Jun 2014) ISSN: 1878-5905 [Electronic] Netherlands
PMID24702959 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Doxorubicin
Topics
  • Antineoplastic Agents (chemistry, pharmacology)
  • Doxorubicin (chemistry, pharmacology)
  • Drug Carriers (chemistry)
  • Drug Resistance, Neoplasm
  • Humans
  • MCF-7 Cells
  • Nanowires (chemistry)

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