Invasive aspergillosis in kidney transplant recipients: a cohort study.

Abstract

OBJECTIVES:

Fungal infections represent 5% of infections in renal transplant recipients. Candidiasis is the most frequent, followed by aspergillosis and cryptococcosis. Invasive aspergillosis is severe and has a poor prognosis, but recent series focused on outcomes are scarce in the literature. We analyzed invasive aspergillosis cases in a cohort of kidney transplant recipients and suggest that prognosis is improved with early diagnosis and treatment.

PATIENTS AND METHODS:

A retrospective study was performed in all kidney transplant undertaken in our hospital from January 1979 to December 2012. The incidence and characteristics of invasive aspergillosis were collected from kidney transplant prospective registry and microbiology laboratory.

RESULTS:

We found 7 invasive aspergillosis cases (6 probable invasive aspergillosis and 1 possible invasive aspergillosis, according to EORTC/IFICG criteria); cumulative incidence 0.78% (7/891). The median posttransplant time until the disease onset was 3.03 months (interquartile range, 2.4-3.2 months), with a mean age of 56 years at the time of diagnosis. Six patients were male. Four patients had previous pulmonary disease. Six patients had received induction therapy (5 anti-IL2R antibodies, 1 with antilymphocytic antibodies). Two patients had received extra immunosuppression (1 with thymoglobulin to treat an acute rejection and the other 1 had a lymphoproliferative disorder and was on chemotherapy). Six patients were on calcineurin inhibitors at the time of diagnosis. Aspergillus fumigatus was the specimen most commonly isolated (6 cases). Six patients had a bacterial coinfection and 1 had a cytomegalovirus coinfection. All patients were treated with antifungal agents; 3 of which received voriconazole. Four patients satisfactorily resolved the episode and 3 died.

CONCLUSIONS:

Invasive aspergillosis incidence is low in kidney transplant although potentially lethal. We observed an acceptable survival of patients analyzed, better than usually reported. A high index of suspicion is essential to get an early diagnosis and start treatment.

• Authors: Maria José Pérez-Sáez, Marisa Mir, Maria Milagro Montero, Marta Crespo, Núria Montero, Julià Gómez, Juan Pablo Horcajada, Julio Pascual
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 12 Issue 2 Pg. 101-5 (Apr 2014) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 24702140 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Immunosuppressive Agents

Topics

• Antifungal Agents (therapeutic use)
• Aspergillus (classification, drug effects, pathogenicity)
• Early Diagnosis
• Female
• Humans
• Immunosuppressive Agents (adverse effects)
• Incidence
• Invasive Pulmonary Aspergillosis (diagnosis, drug therapy, immunology, microbiology, mortality)
• Kidney Transplantation (adverse effects, mortality)
• Male
• Middle Aged
• Predictive Value of Tests
• Registries
• Retrospective Studies
• Risk Factors
• Severity of Illness Index
• Spain (epidemiology)
• Time Factors
• Treatment Outcome