3D bioelectronic interface: capturing circulating tumor cells onto conducting polymer-based micro/nanorod arrays with chemical and topographical control.

Abstract

The three-dimensional (3D) poly(3,4-ethylenedioxythiophene) (PEDOT)-based bioelectronic interfaces (BEIs) with diverse dimensional micro/nanorod array structures, varied surface chemical pro-perties, high electrical conductivity, reversible chemical redox switching, and high optical transparency are used for capturing circulating tumor cells (CTCs). Such 3D PEDOT-based BEIs can function as an efficient clinical diagonstic and therapeutic platform.

• Authors: Yu-Sheng Hsiao, Shyh-Chyang Luo, Shuang Hou, Bo Zhu, Jun Sekine, Chiung-Wen Kuo, Di-Yen Chueh, Hsiao-Hua Yu, Hsian-Rong Tseng, Peilin Chen
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 10 Issue 15 Pg. 3012-7 (Aug 13 2014) ISSN: 1613-6829 [Electronic] Germany
• PMID: 24700425 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Bridged Bicyclo Compounds, Heterocyclic
• Polymers
• poly(3,4-ethylene dioxythiophene)

Topics

• Bridged Bicyclo Compounds, Heterocyclic (chemistry)
• Cell Line, Tumor
• Cell Separation (instrumentation)
• Conductometry (instrumentation)
• Electric Conductivity
• Equipment Design
• Equipment Failure Analysis
• Humans
• Miniaturization
• Nanotubes (chemistry, ultrastructure)
• Neoplastic Cells, Circulating (pathology)
• Polymers (chemistry)
• Surface Properties
• Tissue Array Analysis