Abstract | CONTEXT: OBJECTIVE: MATERIALS AND METHODS: RESULTS: They were characterised for particle morphology, particle size (below 150 nm), zeta potential and polydispersity index (PDI ∼0.35), entrapment efficiency (∼60.23%), and cumulative percent drug release. DISCUSSION: LDNPs in ex-vivo cell line studies on human cancer cell line HepG2 exhibited significantly higher cytotoxicity compared to 5-FU and DNPs (unconjugated PLGA NPs) with growth inhibition 50% (GI50) of 66.7 µg/mL, 50.2 µg/mL and 35.5 µg/mL, respectively. In vivo studies exhibited higher drug concentration about 37.52 ± 0.68% in liver as compared to other organs and plasma. CONCLUSION: Thus, LDNPs showed high drug loading, specificity, biocompatibility and efficacy in treatment of liver cancer.
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Authors | Ruchi Dangi, Pooja Hurkat, Ankit Jain, Satish Shilpi, Ashish Jain, Arvind Gulbake, Sanjay K Jain |
Journal | Journal of microencapsulation
(J Microencapsul)
Vol. 31
Issue 5
Pg. 479-87
( 2014)
ISSN: 1464-5246 [Electronic] England |
PMID | 24697169
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyglycolic Acid
- Lactic Acid
- Fluorouracil
|
Topics |
- Antimetabolites, Antineoplastic
(administration & dosage, pharmacology)
- Carcinoma, Hepatocellular
(drug therapy)
- Drug Delivery Systems
- Fluorouracil
(administration & dosage, pharmacology)
- Hep G2 Cells
- Humans
- Lactic Acid
(chemistry)
- Liver Neoplasms
(drug therapy)
- Nanoparticles
(chemistry)
- Polyglycolic Acid
(chemistry)
- Polylactic Acid-Polyglycolic Acid Copolymer
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