Aberrant phenotypes in peripheral T cell lymphomas.

Abstract

Seventy six peripheral T cell lymphomas were examined immunohistologically to test their reactivity with a panel of monoclonal antibodies against 11 T cell associated antigens (CD1-8, CD27, UCHL1, and the T cell antigen receptor). Sixty two (82%) lymphomas showed aberrant phenotypes, and four main categories were distinguished as follows: (i) lack of one or several pan-T cell antigens (49, 64% of the cases); (ii) loss of both the CD4 and CD8 antigens (11, 15% of the cases); (iii) coexpression of the CD4 and CD8 antigens (13, 17% of the cases); and (iv) expression of the CD1 antigen (eight, 11% of the cases). No correlation was seen between the occurrence of aberrant phenotypes and the histological subtype. It is concluded that the demonstration of an aberrant phenotype is a valuable supplement to histological assessment in the diagnosis of peripheral T cell lymphomas. It is recommended that the panel of monoclonal antibodies against T cell differentiation antigens should be fairly large, as apparently any antigen may be lost in the process of malignant transformation.

• Authors: N Hastrup, E Ralfkiaer, G Pallesen
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 42 Issue 4 Pg. 398-402 (Apr 1989) ISSN: 0021-9746 [Print] England
• PMID: 2469701 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, CD1
• Antigens, Differentiation
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm
• CD8 Antigens

Topics

• Antibodies, Monoclonal
• Antigens, CD1
• Antigens, Differentiation (analysis)
• Antigens, Differentiation, T-Lymphocyte (analysis)
• Antigens, Neoplasm (analysis)
• Biopsy
• CD8 Antigens
• Humans
• Lymphoma (genetics, immunology, pathology)
• Phenotype
• T-Lymphocytes