Abstract | BACKGROUND: Zanthoxylum simullans Hance is a popular natural spice belonging to the Rutaceae family and it is one of the common prescribed herbs in traditional Chinese medicine. MATERIALS AND METHODS: The chemical constituents were mainly isolated and purified by silica gel column chromatography and semi-preparative High Performance Liquid Chromatography. Their structures were identified by comparing the spectral data with those reported in the literature. Cytotoxic activities for the isolated acridone alkaloids were evaluated against two prostate cancer cell lines PC-3M and Lymph Node Carcinoma of Prostate (LNCaP), and their antimalarial activities were tested against two different strains of the parasite Plasmodium falciparum 3D7, and Dd2. RESULTS: CONCLUSION: Normelicopidine was the most active against PC-3M, LNCaP and Dd2 with IC50 values of 12.5, 21.1, and 18.9 ug/mL respectively.
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Authors | Chao Wang, Jinfu Wan, Zhinan Mei, Xinzhou Yang |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
Vol. 10
Issue 37
Pg. 73-6
(Jan 2014)
ISSN: 0973-1296 [Print] India |
PMID | 24696549
(Publication Type: Journal Article)
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