Novel submicronized rebamipide liquid with moderate viscosity: significant effects on oral mucositis in animal models.

Abstract

This study aimed at developing a novel rebamipide liquid for an effective treatment of oral mucositis. The healing effects of a variety of liquids comprising submicronized rebamipide crystals were investigated using a rat cauterization-induced oral ulcer model. Whereas 2% rebamipide liquid comprising micro-crystals did not exhibit significant curative effect, 2% rebamipide liquids comprising submicronized crystals with moderate viscosities exhibited healing effects following intra-oral administration. The 2% and 4% optimized rebamipide liquids showed significant healing effects in the rat oral ulcer model (p<0.01). In addition, in the rat radiation-induced glossitis model, whereby the injury was caused to the tongue by exposing only around the rat's snout to a 15 Gy of X-irradiation, the 2% optimized rebamipide liquid significantly reduced the percent area of ulcerated injury (p<0.05). In conclusion, the submicronized rebamipide liquid with moderate viscosity following intra-oral administration showed better both healing effect in the rat oral ulcer model and preventive effect in the rat irradiation-induced glossitis model.

• Authors: Takako Nakashima, Nobutomo Sako, Takakuni Matsuda, Naoya Uematsu, Kazushi Sakurai, Tatsuhiro Ishida
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 37 Issue 4 Pg. 671-8 ( 2014) ISSN: 1347-5215 [Electronic] Japan
• PMID: 24694614 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Drug Carriers
• Quinolones
• rebamipide
• Alanine

Topics

• Administration, Oral
• Alanine (administration & dosage, analogs & derivatives, chemistry, therapeutic use)
• Animals
• Anti-Ulcer Agents (administration & dosage, chemistry, therapeutic use)
• Cautery
• Disease Models, Animal
• Drug Carriers (administration & dosage)
• Glossitis (drug therapy)
• Male
• Nanoparticles (administration & dosage)
• Oral Ulcer (drug therapy)
• Quinolones (administration & dosage, chemistry, therapeutic use)
• Rats
• Stomatitis (drug therapy)
• Viscosity
• X-Rays