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[Patient with bulky duodenum GIST became complete resection possible after primary systemic therapy: a case report].

Abstract
A case was a 77 years old male. Exertional breathlessness was a chief complaint, and anemia was pointed out. A duodenum GIST was detected by gastroscopy. The CT scan showed infiltration in an inferior vena cava, the right kidney, and an ascending colon, so we judged that radical cure resection was difficult. We started Imatinib medication. Six months after the medication start, because the border with surroundings also became clear, we became a plan of the operation. The tumor existed in the descending limb of duodenum and the distance with papilla Vater was maintained, so the complete excision by duodenal portion resection was possible for it. Although meaning of primary systemic therapy for GIST was not established, it was shown that medicating Imatinib to the high-level partial advance GIST before an operation may become an effective cure which avoids an extended operation and makes complete resection of a tumor possible.
AuthorsHajime Otsu, Eiji Oki, Hiroyuki Kawano, Koji Ando, Shuhei Ito, Keishi Sugimachi, Hiroshi Saeki, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Masaru Morita, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Tetsuo Ikeda, Yoshihiko Maehara
JournalFukuoka igaku zasshi = Hukuoka acta medica (Fukuoka Igaku Zasshi) Vol. 104 Issue 12 Pg. 585-8 (Dec 2013) ISSN: 0016-254X [Print] Japan
PMID24693689 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
Topics
  • Aged
  • Antineoplastic Agents (administration & dosage)
  • Benzamides (administration & dosage)
  • Chemotherapy, Adjuvant
  • Digestive System Surgical Procedures
  • Duodenal Neoplasms (diagnosis, pathology, surgery)
  • Duodenum (surgery)
  • Gastrointestinal Stromal Tumors (diagnosis, pathology, surgery)
  • Humans
  • Imatinib Mesylate
  • Male
  • Neoplasm Invasiveness
  • Piperazines (administration & dosage)
  • Preoperative Care
  • Pyrimidines (administration & dosage)
  • Tomography, X-Ray Computed
  • Treatment Outcome

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